Pharmaceutical Biotechnology (Theory) Semester 6 Notes | Handwritten Notes for Pharmacy Students

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Scope:

1. Biotechnology has a long promise to revolutionize the biological sciences and technology. 
2. Scientific application of biotechnology in the field of genetic engineering, medicine and fermentation technology makes the subject interesting.
3. Biotechnology is leading to new biological revolutions in diagnosis, prevention and cure of diseases, new and cheaper pharmaceutical drugs. 
4. Biotechnology has already produced transgenic crops and animals and the future promises lot more. 
5. It is basically a research-based subject

Objectives: Upon completion of the subject student shall be able to;

1. Understanding the importance of Immobilized enzymes in Pharmaceutical
Industries
2. Genetic engineering applications in relation to production of pharmaceuticals
3. Importance of Monoclonal antibodies in Industries
4. Appreciate the use of microorganisms in fermentation technology

Download Semester wise PDFs,MCQs and Notes :-
Semester 1 :- Click here 
Semester  2 :- Click here 
Semester  3 :- Click here 
Semester  4 :- Click here 
Semester  5 :- Click here 
Semester  6 :- Click here 
Semester  7 :- Click here 
Semester  8 :- Click here

Syllabus Content:

Unit I
a) Brief introduction to Biotechnology with reference to Pharmaceutical Sciences.
b) Enzyme Biotechnology- Methods of enzyme immobilization and applications.
c) Biosensors- Working and applications of biosensors in Pharmaceutical Industries.
d) Brief introduction to Protein Engineering. 
e) Use of microbes in industry. Production of Enzymes- General consideration - Amylase, Catalase, Peroxidase, Lipase, Protease, Penicillinase. 
f) Basic principles of genetic engineering

Unit II
a) Study of cloning vectors, restriction endonucleases and DNA ligase. b) Recombinant DNA technology. Application of genetic engineering in medicine.
c) Application of r DNA technology and genetic engineering in the production of:
i) Interferon ii) Vaccines- hepatitis- B iii) Hormones-Insulin.
d) Brief introduction to PCR

Unit III
Types of immunity- humoral immunity, cellular immunity
a) Structure of Immunoglobulins
b) Structure and Function of MHC
c) Hypersensitivity reactions, Immune stimulation and Immune suppressions.
d) General method of the preparation of bacterial vaccines, toxoids, viral vaccine, antitoxins, serum-immune blood derivatives and other products relative to immunity. 
e) Storage conditions and stability of official vaccines
f) Hybridoma technology- Production, Purification and Applications
g) Blood products and Plasma Substituties

Unit IV
a) Immuno blotting techniques- ELISA, Western blotting, Southern blotting. 
b) Genetic organization of Eukaryotes and Prokaryotes
c) Microbial genetics including transformation, transduction, conjugation, plasmids and transposons.
d) Introduction to Microbial biotransformation and applications.
e) Mutation: Types of mutation/mutants

Unit V
a) Fermentation methods and general requirements, study of media, equipments,
sterilization methods, aeration process, stirring. 
b) Large scale production fermenter design and its various controls.
c) Study of the production of - penicillins, citric acid, Vitamin B12, Glutamic acid, Griseofulvin,
d) Blood Products: Collection, Processing and Storage of whole human blood, dried human plasma, plasma Substituties

Download Following Chapters:-

Unit I
a) Brief introduction to Biotechnology with reference to Pharmaceutical Sciences.
b) Enzyme Biotechnology- Methods of enzyme immobilization and applications.
c) Biosensors- Working and applications of biosensors in Pharmaceutical Industries.
d) Brief introduction to Protein Engineering. 
e) Use of microbes in industry. Production of Enzymes- General consideration - Amylase, Catalase, Peroxidase, Lipase, Protease, Penicillinase. 
f) Basic principles of genetic engineering

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Download (optional link)

Unit II
a) Study of cloning vectors, restriction endonucleases and DNA ligase. b) Recombinant DNA technology. Application of genetic engineering in medicine.
c) Application of r DNA technology and genetic engineering in the production of:
i) Interferon ii) Vaccines- hepatitis- B iii) Hormones-Insulin.
d) Brief introduction to PCR

Download 
Download (optional link)

Unit III
Types of immunity- humoral immunity, cellular immunity
a) Structure of Immunoglobulins
b) Structure and Function of MHC
c) Hypersensitivity reactions, Immune stimulation and Immune suppressions.
d) General method of the preparation of bacterial vaccines, toxoids, viral vaccine, antitoxins, serum-immune blood derivatives and other products relative to immunity. 
e) Storage conditions and stability of official vaccines
f) Hybridoma technology- Production, Purification and Applications
g) Blood products and Plasma Substituties

Download 
Download (optional link)

Unit IV
a) Immuno blotting techniques- ELISA, Western blotting, Southern blotting. 
b) Genetic organization of Eukaryotes and Prokaryotes
c) Microbial genetics including transformation, transduction, conjugation, plasmids and transposons.
d) Introduction to Microbial biotransformation and applications.
e) Mutation: Types of mutation/mutants

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Unit V
a) Fermentation methods and general requirements, study of media, equipments,
sterilization methods, aeration process, stirring. 
b) Large scale production fermenter design and its various controls.
c) Study of the production of - penicillins, citric acid, Vitamin B12, Glutamic acid, Griseofulvin,
d) Blood Products: Collection, Processing and Storage of whole human blood, dried human plasma, plasma Substituties.

Download 
Download (coming soon)

Also Download:
MCQs on Introduction of Glycosides:-Click here 
MCQs on Introduction of pharmacognosy :- Click here
Download and Read B pharmacy MCQs :- Click here 
MCQs From Pharmaceutical Engineering (include all chapters):- Click here 
MCQs From Biopharmaceutics and Pharmacokinetics (include all chapters) :- Click here
MCQs From Tablet chapter :- Click here 
MCQs From Pharmaceutical Jurisprudence (include all chapters):-Click here 
MCQs on Introduction of Alkaloids:- Click here
Human Anatomy and Physiology-I :- Click here 
MCQs on Introduction of Volatile Oils:-Click Here 
MCQs From Pathophysiology (include all chapters):-Click here 
Check other important Question Papers:- Click here 
MCQs From Hospital and Clinical Pharmacy(include all chapters): Click here

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